Many of the chromosomal regions identified in this study contain tumour genes already implicated in the tumorigenesis of HNSCC including 3p14 (fhit), 7p12 (EGFR), 7q31 (ING3), 8q24 (c-myc), 9p (p16), 11q13 (ccnd1) and 17p (p53). This evidence concerns the gene FHIT and head and neck squamous cell carcinoma.