In agreement with the CGH findings of 12q gain, candidates within this chromosomal region, such as sarcoma amplification sequence (SAS), human homologue of murine double minutes 2 (MDM2), cyclin-dependent kinase 4 (CDK4), and high-mobility group protein IC (HMGIC) have been shown to be amplified in MFH by molecular analyses (Nilbert et al, 1995). The gene discussed is CDK4; the disease is sarcoma.