Christensen et al (1995) and Khan et al, (2002) could not find significant correlation of either EGFR or Her-2 with clinicopathological features or prognosis; however, Bei et al (2001) and Xia et al (1999) found colocalisation of both molecules in oral cancer tissues and the combined use of these molecules is a stronger predictor for the cancer prognosis. This evidence concerns the gene ERBB2 and cancer.