These include age less than 2 months at diagnosis, biological markers such as elevated serum lactate dehydrogenase (LDH), ferritin or neuron-specific enolase (NSE) levels, histopathological as well as genetic markers such as N-myc amplification (NMA) and tumour diploidy (Seeger et al, 1985; Look et al, 1991; Evans et al, 1996; Katzenstein et al, 1998). Here, ENO2 is linked to neoplasm.