However, there was no overall increase in the VEGFR3 positive vessel count in tumour stroma compared with normal gastric mucosa when both VEGF-C mRNA positive and negative tumours were considered together (4.62±5.85 vs 2.48±1.64, P=0.067) (Yonemura et al, 2001). This evidence concerns the gene FLT4 and neoplasm.