Recent randomized trials in post-menopausal women suggest that mechanisms underlying the protective effect of alcohol on CHD risk may include improvements in risk factors and conditions associated with CHD, such as blood cholesterol levels (i.e., reductions in LDL, or “bad” cholesterol, and increases in HDL, or “good” cholesterol) (Baer et al. 2002) as well as reductions in fasting insulin levels and increased insulin sensitivity (Davies et al. 2002). This evidence concerns the gene INS and coronary artery disorder.