The absolute reticulocyte count and soluble transferrin receptor levels were increased (p < 0.001) in heterozygous beta-thalassemia (mean ± standard deviation, SD: 160.1 ± 137.8 x 109/liter and 27.1 ± 15.8 nmol/liter, respectively) and iron-deficiency anemia (mean ± SD: 93.7 ± 52.4 x 109/liter and 50.2 ± 21.4 nmol/liter, respectively), in comparison with the control group (mean ± SD: 67.9 ± 17.6 x 109/liter and 16.8 ± 3.1 nmol/liter, respectively). This evidence concerns the gene TFRC and Iron deficiency anemia.