TP53 and cervical carcinoma: In a study to determine p53 mutation by polymerase chain reaction/single-strand conformation polymorphism and sequencing techniques, point mutation was detected in 11% (5/46) of HPV-infected cervical carcinoma and no mutation was found in two HPV-negative cases.21 The rapid progress of squamous invasive cancer observed in our sample may suggest a synergic effect of the two events.