This is based on observations of constitutive activation of NF-κB in pancreatic cancer cells (Wang W et al, 1999) as well as the fact that inhibition of NF-κB decreases cell survival (Shah et al, 2001) and enhances the apoptotic effect of chemotherapy in pancreatic cancer cells (Arlt et al, 2001). The gene discussed is NFKB1; the disease is familial pancreatic carcinoma.