Considering that elevated level of uPAR is associated with negative prognosis of colon cancer (Ganesh et al, 1994) and is observed in invasive colon tumours (Ganesh et al, 1994; Wang, 2001), the impact of uPAR/β1 integrin complexes in colon cancer invasion and metastasis needs to be evaluated. This evidence concerns the gene PLAUR and malignant colon neoplasm.