After 96 h, IL-6 treatment of PL10 resulted in significant increases in cell number (120.5±21.9%, P=0.015) compared to untreated cells, whereas two other pancreatic cancer cell lines, Panc1 and PL12, and the non-neoplastic HPDE cells did not change their growth patterns in response to IL-6 (Panc1: 111±20.8% (P=0.146), PL12: 116±7.41% (P=0.109), HPDE: 98.7±16.4% (P=0.807)) (Figure 3A). Here, IL6 is linked to familial pancreatic carcinoma.