Recently, it was reported that alterations in the FHIT locus detected by DNA and/or reverse transcription–PCR analysis correlated with a loss of Fhit protein expression in lung, cervical, and breast carcinomas (Greenspan et al, 1997; Sozzi et al, 1997a,1997b; Campiglio et al, 1999). The gene discussed is FHIT; the disease is breast carcinoma.