TP53 and neoplasm: The loss of Fhit expression and p53 overexpression was significantly more common in tumours occurring in smokers (93 out of 113, 82% and 56 out of 113, 50%) than in those of nonsmokers (63 out of 150, 42%; P<0.001 and 33 out of 150, 22%; P<0.001).