It was also reported that there was no correlation between Fhit protein expression with the histotype, tumour stage, survival (Sozzi et al, 1997a,1997b; Geradts et al, 2000) and abnormalities of immunohistochemical expression of p53, Rb, and p16 (Geradts et al, 2000). Here, FHIT is linked to neoplasm.