Loss of expression of pRB was observed in 37% of tumours (40 of 108), a number corresponding well with the findings of other studies (Geradts et al, 1994; Cordon-Cardo et al, 1997; Pollack et al, 1997a, 1997b; Cote et al, 1998; Moonen et al, 2001). The gene discussed is RB1; the disease is neoplasm.