RB1 and urinary bladder cancer: In striking contrast to these findings, when pRB status has been studied in a series of purely surgically managed bladder cancer, loss of pRB expression has consistently been related to aggressive disease course and decreased survival (Cordon-Cardo et al, 1992; Logothetis et al, 1992; Cordon-Cardo et al, 1997; Cote et al, 1998; Grossman et al, 1998).