In 212 postmenopausal women with node-positive oestrogen receptor-positive (ERLBA) breast cancer subjected to radical surgery and adjuvant tamoxifen, the risk of 6-year relapse increased with increasing values of intratumoral vascular endothelial growth factor (VEGF) in patients whose tumours had a low/intermediate ERLBA content compared to patients with high-ERLBA tumours. This evidence concerns the gene VEGFA and neoplasm.