TNFSF10 and neoplasm: Apo2L/TRAIL is a new member of the tumour necrosis factor (TNF)-cytokine family that induces cell death in a wide variety of tumour cell lines, but does not seem to be cytotoxic to many normal cell types in vitro or in vivo (Ashkenazi et al, 1999; Walczak et al, 1999; Atkins et al, 2002; Evdokiou et al, 2002).