Several reports (Gliniak and Le, 1999; Desjosez et al, 2000; Gibson et al, 2000; Nagane et al, 2000; Yamanaka et al, 2000; Lacour et al, 2001; Mizutani et al, 2001), including our own (Evdokiou et al, 2002), have demonstrated that chemotherapeutic drugs augment Apo2L/TRAIL-induced apoptosis of sensitive, and more importantly Apo2L/TRAIL-resistant, cancer cells. This evidence concerns the gene TNFSF10 and cancer.