Previous studies of our group demonstrated that a specific cytotoxic T-cell (CTL) response ex vivo could be elicited from healthy donor PBMC as well as tumour-infiltrating lymphocytes (TILs) derived from prostate carcinoma bone metastases stimulated in vitro with autologous dendritic cells (DC) pulsed with peptide epitopes derived from PTH-rP-expressing HLA-A(*)02.01-binding amino-acid consensus motifs (Correale et al, 2001a; Francini et al, 2002). This evidence concerns the gene BLOC1S3 and neoplasm.