RARRES3 along with HREV107 (Hajnal et al, 1994; Husmann et al, 1998)and A-C1 (Akiyama et al, 1999) belong to a family of class II tumour-suppressor genes that block reversible expression rather than sustained mutation, as a general mechanism of gene inactivation (Sager R, 1997). The gene discussed is PLAAT4; the disease is neoplasm.