In contrast, transregulatory mechanisms appear to be responsible for the high levels of Bcl-2 protein production that occur in many different solid tumours such as prostate cancer (Colombel et al, 2000), breast cancer (Silvestrini et al, 1994) and lung cancer (Pezzella et al, 1993; Fontanini et al, 1995). The gene discussed is BCL2; the disease is lung cancer.