SERPINA1 and neoplasm: The enhanced antitumour effect of chemotherapeutic agents when combined with AAT (Teicher et al, 1992, 1994; Sweeney et al, 2001) is probably not only due to differences in vascularisation, perfusion and drug delivery, but also an increase in tumour cell apoptosis (Kamiya et al, 1999; Wassberg et al, 1999).