In this study, we have demonstrated that the most potent antiresorptive nitrogen-containing BP ZOL causes antiproliferative effects, perturbation of the p21ras/Raf1/MEK/ERK1-2 mitogenic pathway and pKB/Akt survival signalling, and also induces apoptotic death of human PC cells in vitro. This evidence concerns the gene MAPK3 and pachyonychia congenita.