CCNE1 and cancer: Moreover, on the other hand, increased expression of cyclin E is a common event in a variety of human malignancies (Donnellan and Chetty, 1999; Sandhu and Slingerland, 2000) and is believed to play an important role in cancer development and progression by causing cell growth deregulation and genomic instability (Bortner and Rosenberg, 1997; Spruck et al, 1999).