TNF and neoplasm: Further preclinical studies at the Auckland Cancer Society Research Centre (ACSRC) showed that FAA induced TNF production, acute tumour vascular collapse, haemorrhagic necrosis of tumours and enhanced activity of immune effector cells (Ching and Baguley, 1987; Smith et al, 1987; Finlay et al, 1988; Zwi et al, 1989, 1992) (Zwi et al, 1990 ID: 286).