Additionally, tumours from mice treated with the combination of the MMP and COX-2 inhibitors had a 2.5-fold increase in the apoptotic index (3.22±0.97%; P=0.0090) compared to tumours from mice treated with vehicle; however, there was no significant increase in the rate of apoptosis over treatment with either MMPI or COX-2I alone (Figure 3A). The gene discussed is PTGS2; the disease is neoplasm.