The prostate is known to express FGFR1, 2 and 3, while FGFR4 has only been detected at low levels in prostate cancer cell lines (Story et al, 1994; Ittman and Mansukhani, 1997; Giri et al, 1999; Ropiquet et al, 2000). This evidence concerns the gene FGFR4 and Familial prostate cancer.