These results agree with the finding that specific genetic aberrations characterise the different subtypes of RCC (Kovacs et al, 1997), although none of the genes for cyclin D1 (11q3), cyclin D3 (6p21), or cyclin E (19q12-13) are mapped to the chromosomes with characteristic abnormalities in RCC (Inaba et al, 1992; Demetrick et al, 1995; Kovacs et al, 1997). This evidence concerns the gene CCNE1 and renal cell carcinoma.