The association between low cyclin D1 and poor prognosis in the univariate analysis agrees with the data reported for breast cancer (Gillet et al, 1996; Nielsen et al, 1997; Hwang et al, 2002; McKay et al, 2002), although an association between high cyclin D1 and poor prognosis has been reported in many malignancies (Åkervall et al, 1997; Gansauge et al, 1997). This evidence concerns the gene CCND1 and breast cancer.