The combination of TRAIL with IR might become another therapeutic option in order to overcome apoptosis resistance of tumour cells and several reports could actually demonstrate an additive or synergistic effect in different tumour models (Chinnaiyan et al, 2000; Gong and Almasan, 2000; Belka et al, 2001; Di Pietro et al, 2001; Kim et al, 2001a; Ravi et al, 2001). This evidence concerns the gene TNFSF10 and neoplasm.