CDH2 and neoplasm: In addition, because the tumour angiogenesis was also reported to be essential to tumour growth and metastasis (Folkman, 1990, 1995), we evaluated intratumoural microvessel density (IMD) using anti-CD34 monoclonal antibody to study the correlation between N-cadherin expression and tumour angiogenesis (Matsuyama et al, 1998).