For instance, Meijers-Heijboer et al (2001) report that of 139 women with a BRCA1/2 mutation, 55% choose to undergo prophylactic mastectomy of whom none developed breast cancer, whereas 45% opted for an intensive-screening programme of whom 12% developed breast cancer within 2.9 years of follow-up. Here, BRCA1 is linked to breast cancer.