NFKBIA and metastatic melanoma: For instance, in prostate cancer cells and metastatic melanoma cells, the blockade of NF-κB by a nondegradable dominant-negative IκBα mutant suppresses angiogenesis, invasion and metastasis (Huang et al, 2000,2001), and may reduce the apoptotic effects associated with NF-κB signalling (Baldwin, 1996).