While a similar pattern has been exhibited by apoptotic T-cells with an enhanced release of active TGF-β1 without major changes in the mRNA expression (Chen et al, 2001), one may also consider the possibility that the observed upregulation of TGF-β mRNA in prostate cancer cells could be a consequence of doxazosin-induced apoptosis. The gene discussed is TGFB1; the disease is Familial prostate cancer.