CHUK and adenomatous colon polyp: Although NF-κB has been previously shown to be expressed at high levels in human colonic adenomatous polyps, our investigations have demonstrated for the first time (to the best of our knowledge) that IKKα, cytoplasmic inactive NF-κB-p65 protein and putative active endonuclear NF-κB-p65 protein are significantly increased in malignant colorectal epithelial cells.