The predominant gelatinase expressed by macrophages and neutrophils in inflammatory conditions such as emphysema, asthma, sepsis and inflammatory bowel disease is MMP-9 (Finlay et al, 1997; Mautino et al, 1997; Pugin et al, 1999), which is in keeping with the significantly elevated activity of this enzyme seen in IP specimens compared to either MM or UP samples. This evidence concerns the gene MMP9 and inflammatory bowel disease.