Although the role in the pathology of carcinomas of epithelial origin is not clear, Visvader et al 2001 recently indicated that LMO4 and LDB1 are required to maintain the undifferentiation state of invasive breast carcinoma cells, and the forced expression of LMO4 inhibits differentiation of mammary epithelial cells. Here, LDB1 is linked to invasive breast carcinoma.