In contrast to the negligible expression of LDB2, LMO4 and LDB1 were frequently detected in the less-differentiated carcinomas and carcinoma cells at the invasive front, and upregulated in metastasised lymph nodes, suggesting an involvement of the LMO4–LDB1 transcriptional complex in the pathology of carcinoma progression. Here, LDB2 is linked to carcinoma.