In the former case, demethylating agents, such as 5-aza-2′-deoxycytidine, or IFN-γ can restore caspase-8 gene expression in NB cells (Fulda et al, 2001; Banelli et al, 2002; Fulda and Debatin, 2002), whereas this cannot happen in the latter case. The gene discussed is CASP8; the disease is neuroblastoma.