Soon after discovery, it was shown that the FRA3B/FHIT locus frequently exhibits deletions in preneoplasias and cancers, Fhit protein expression is lost or reduced in the majority of human cancers, and the orthologous mouse Fhit locus is fragile and exquisitely sensitive to carcinogen damage (Huebner et al, 1998; Huebner and Croce, 2001). Here, FHIT is linked to cancer.