In a follow-up study that included preinvasive lesions, Connolly et al (2000) examined Fhit expression in 95 invasive cervical carcinomas, 33 high-grade squamous intraepithelial lesions (HSILs) associated with concurrent cancer, 38 HSILs without associated cancer and 24 low-grade squamous intra-epithelial (LSILs) lesions. The gene discussed is FHIT; the disease is cancer.