Interestingly, in a study of biopsies of periocular sebaceous gland carcinomas, of patients with Muir–Torre syndrome, Holbach et al (2002) determined that Fhit was detectable in the one sebaceous gland carcinoma with microsatellite instability but not in the five sebaceous carcinomas without microsatellite instability. Here, FHIT is linked to sebaceous adenocarcinoma.