FHIT and cervical squamous intraepithelial neoplasia: Butler et al (2002) also studied CIN and microinvasive carcinoma (MICA) for expression of Fhit protein by immuno-histochemistry and looked for association of Fhit loss with clinical parameters, including high-risk HPV infection; 50% of CIN3 and 78% of MICA lesions showed reduction or absence of Fhit protein, while CIN1 lesions showed moderate to strong Fhit expression.