A multi-institutional study – the "Sunbelt Melanoma Trial" – has addressed issues regarding the relative clinical significance of microscopic nodal disease determined by histology, immunohisto-pathology and reverse transcriptase-polymer-ase chain reaction analysis, using four molecular markers, MAGE III, MART-1, GP 100 (glycoprotein 100) and Tyrosinase.26 The gene discussed is TYR; the disease is melanoma.