HLA-C and neoplasm: Introduction of such chimeric genes into T cells enables them to respond in an MHC-independent fashion to an antigen-specific trigger via these receptors by cytokine production (Altenschmidt et al, 1997; Eshhar et al, 2001; Maher et al, 2002) and tumour cell lysis (Eshhar et al, 1993; Moritz et al, 1994; Hwu et al, 1995; Weijtens et al, 1996).