Since the present day populations of Scotland and Northern Ireland remain relatively homogeneous, and distinct from those of other parts of the UK (Bodmer et al, 1987; Liede et al, 2000), we have collated information on all BRCA1 and BRCA2 mutations recorded among families attending breast cancer genetics clinics in Aberdeen, Belfast, Dundee, Edinburgh or Glasgow. This evidence concerns the gene BRCA2 and breast carcinoma.