BRCA1 and ovarian carcinoma: For BRCA1, two studies published in 1995 indicated that the relative risk of ovarian cancer was substantially higher for mutations occurring in the 5′ two-thirds of the gene (Gayther et al, 1995; Shattuck-Eidens et al, 1995) but this was not confirmed in three other reports (Serova et al, 1996; Couch et al, 1997; Frank et al, 1998) and is not apparent in a fourth (Eccles et al, 1998), where the data are presented but not discussed in detail.