FHIT and cervical squamous intraepithelial neoplasia: It was reported that Fhit protein expression was markedly reduced or absent in 67 out of 95 (71%) invasive cancer tissues, 17 out of 33 (52%), and eight out of 38 (21%) in high-grade CIN tissues associated or unassociated with invasive cancer, respectively (Connolly et al, 2000).