SAT1 and malignant colon neoplasm: In fact, as reported recently (Turchanowa et al, 2001), treatment of colon cancer cells with indomethacin (a nonselective COX-1 and COX-2 inhibitor) induced an irreversible cascade of events leading to oxidative stress, activation of spermidine/spermine-acetyltransferase (SSAT), polyamine depletion, and cell death.