In fact, a previous immunohistochemistry study, with two recombinant antitenascin antibodies, showed that 96 different tumours, including brain, breast and lung, were all strongly positive with the antibody recognising an epitope shared by small and large tenascins, while only 28 were positive with the other antibody recognising an epitope within the alternatively spliced region (Carnemolla et al, 1999). This evidence concerns the gene TNC and neoplasm.