In contrast, other groups have shown that Bcl-2-transfected 8226 and ARP-1 myeloma cells still remained sensitive to TRAIL (Gazitt, 1999a,1999b) and that Bcl-2 failed to block cytochrome c release after exposure to TRAIL (Keogh et al, 2000; Walczak et al, 2000). This evidence concerns the gene BCL2 and plasma cell myeloma.