Kitazono et al (1999) recently provided the first evidence favouring a causal relation between vaults and drug resistance. Moreover, basal LRP expression has been found indicative for cisplatin and carboplatin resistance (nonclassical MDR-related drugs) in the NCI panel of 61 unselected human tumour cell lines used for drug screening (Izquierdo et al, 1996a), and in nonsmall-cell lung cancer cell lines (Berger et al, 2000). Here, MVP is linked to lung cancer.