For example, fibronectin and tenascin are upregulated in breast cancer (Mackie et al, 1987; Loridon-Rosa et al, 1988; Koukoulis et al, 1993; Ishihara et al, 1995; Takei et al, 1995,1998; Jahkola et al, 1996), while laminin-5 expression is increased in gliomas, gastic carcinomas, and squamous carcinomas, but downregulated in prostate and breast carcinomas (Martin et al, 1988). The gene discussed is TNC; the disease is central nervous system cancer.