For example, fibronectin and tenascin are upregulated in breast cancer (Mackie et al, 1987; Loridon-Rosa et al, 1988; Koukoulis et al, 1993; Ishihara et al, 1995; Takei et al, 1995,1998; Jahkola et al, 1996), while laminin-5 expression is increased in gliomas, gastic carcinomas, and squamous carcinomas, but downregulated in prostate and breast carcinomas (Martin et al, 1988). This evidence concerns the gene TNC and squamous cell carcinoma.