Since wild-type p53 protein mediates degradation of ΔNp63 in vitro (Ratovitski et al, 2001) and actually p53 mutations strongly relate to overexpression of ΔNp63 in squamous cell carcinoma (Hibi et al, 2000), we investigated the possible association of p53 status with impaired ΔNp63 expression in urothelial carcinoma. This evidence concerns the gene TP53 and urothelial carcinoma.