Hepatic overexpression of the IGF-2 gene has been observed in animal models of hepatocarcinogeneses (Norstedt et al, 1988; Harris et al, 1998) as well as in human HCC (Sohda et al, 1996; Cariani et al, 1988), often on the background of HBV- and HCV-related chronic disease (d'Arville et al, 1991; Nardone et al, 1996). This evidence concerns the gene IGF2 and hepatocellular carcinoma.