CDH1 and cancer: In various cancerous tissues, a reduced expression of E-cadherin has frequently been observed in cancer progression (Katagiri et al, 1995; Lipponen and Eskelinen, 1995; Yonemura et al, 1995; Tamura et al, 1996; Nakanishi et al, 1997; Umbas et al, 1997; Bankfalvi et al, 1999; Ghadimi et al, 1999; Zheng et al, 1999; Kase et al, 2000; Gofuku et al, 1999).