PTGS2 and cancer: A specific target of the protection against colorectal and other cancers by aspirin and other NSAID is the inhibition of cyclooxygenase-2, which is important for apoptosis, and therefore for control of the mechanisms of carcinogenesis (Featherstone, 1997; Hong and Sporn, 1997; Taketo, 1998a,1998b; Smith et al, 2000).