IL2 and neoplasm: The finding that tumour-induced degradation of signalling molecules can be ‘reverted’, and proliferative and cytotoxic activities of TIL restored by culture with exogenous cytokines (especially IL-2), at least in vitro, has important potential therapeutic implications (Salvadori et al, 1993; Rabinowich et al, 1996; Zier et al, 1996), although data about the in vivo effects of cytokines administration on T-cell signalling molecules of cancer patients are still scarce (Farace et al, 1994; Rabinowich et al, 1996).