A number of other candidate tumour suppressor genes are also located within this region (STC1, ADAMDEC1, EXTL3, DOK2, DPYSL2, CLU and NKX3A), but further refinement of the region by LOH analysis of primary tumours or monochromosome-mediated chromosome transfer (MMCT) may be necessary before identification of the tumour suppressor is possible. Here, CLU is linked to neoplasm.