The BNIP3L gene is located between markers D8S1752 and D8S1989 that map to 8p21 in the smallest region of overlap (SRO) identified by LOH analysis of breast and ovarian tumours (Seitz et al, 2000; Brown et al, 1999), and to a region of prostate cancer metastasis suppression (Nihei et al,, 1996).BNIP3L encodes a protein that is homologous to the proapoptotic protein BNIP3 (Matsushima et al, 1998; Chen et al, 1999; Imazu et al, 1999; Yasuda et al, 1999). Here, BNIP3L is linked to Familial prostate cancer.