A significant association between the levels of detection of VEGF-C and VEGFR-3 has also been found in malignant mesothelioma, gastric carcinoma and nonsmall cell lung carcinoma (Ohta et al, 1999; Yonemura et al, 1999; Kajita et al, 2001), whereas there was no association between VEGF-D and VEGFR-3 detection in colorectal carcinoma (White et al, 2002). Here, FLT4 is linked to malignant mesothelioma.