FLT4 and oral cavity squamous cell carcinoma: While VEGFR-3 protein levels were not related to lymphatic spread in gastric and breast carcinoma (Yonemura et al, 1999; Jacquemier et al, 2000), VEGFR-3 detection was found to predict the presence of lymphatic metastases in oral squamous cell carcinoma (Moriyama et al, 1997).